GENOTOXICITY, DNA MARKERS, AND TOXICOLOGY
Provided by Isaac Wirgin, New York University, Institute of Environmental
Medicine
Summary Papers
Roesijadi G. 1992. Metallothioneins in metal regulation and .HTMLity in
aquatic animals. Aquat. Toxicol. 22:81-114.
Stegeman, J.J. and Mark E. Hahn. 1993. Biochemistry and molecular biology
of monooxygenases: Current perspectives on forms, functions, and regulation
of cytochrome P450 in aquatic species. in D.C. Malins an G.K. Ostrander,
eds. Aquatic Toxicology: Molecular, Biochemical, and Cellular Perspectives,
Lewis Pub., Boca Raton.
Stegeman, J.J., M. Brouwer, R.T. Di Giulio, L. Forlin, B.A. Fowler, B.M.
Sanders, and P.A. Van Veld. 1992. Enzyme and protein synthesis as indicators
of contaminant exposure and effect. in R.J. Huggett, R.A. Kimerle, P.M.
Mehrle, Jr., and H.L. Bergman, eds. Biomarkers: Biochemical, Physiological,
and Histological Markers of Anthropogenic Stress, Lewis Pub, Chelsea, MI.
Van Bendeden, R.J., and G. K. Ostrander. 1993. Expression of oncogenes and
tumor supressor genes in teleost fish. in D.C. Malins and G.K. Ostrander,
eds. Aquatic Toxicology: Molecular, Biochemical, and Cellular Perspectives,
Lewis Pub., Boca Raton.
Recent Papers
Fong, A.T., R.H. Dashwood, R. Cheng, C. Mathews, B. Ford, J.D. Hendricks,
and G.S. Bailey. 1993. Carcinogenicity, metabolism and Ki-ras proto-oncogene
activation by 7,12-dimethylbenz[a]anthracene in rainbow trout. Carcinogenesis
14:629-635.
Hahn, M.E., A. Poland, E. Glover, and J.J. Stegeman. 1994. Photoaffinity
labeling of the AH receptor: phylogenetic survey of diverse vertebrate and
invertebrate species. Arch. Biochem. Biophys. 310:218-228.
McMahon, G., L.J. Huber, M.J. Moore, J.J. Stegeman, and G.N. Wogan. 1990
Mutations in c-Ki-ras oncogenes in diseased livers of winter flounder from
Boston Harbor. Proc. Natl. Acad. Sci. USA. 87:841-845.
Varanasi, U., W.L. Reichet, and J.E. Stein. 1989. 32P-postlabeling analysis
of DNA adducts in liver of wild English sole (Parophrys vetulus) and winter
flounder (Pseudopleuronectes americanus). Cancer Res. 49:1171-1177.
Wirgin, I., D.C. Currie, and S.J. Garte. 1989. Activation of the K-ras oncogene
n liver tumors of Hudson River tomcod. Carcinogenesis 10:2311-2315.
Wirgin, I.I., C. Grunwald, S. Courtenay G.-L. Kreamer, W.L. Reichert, and
J.E. Stein. 1994. A biomarker approach to assessing xenobiotic exposure
in Atlantic tomcod from the North American Atlantic coast. Environ. Health
Perspect. 102:764-770.
Controversy
What is the role of oxygen radicals in comparison to bulky PAH adducts in
the initiation of DNA damage in cancer-prone fish?
Kurelec, B., A. Garg, S. Krca, M. Chacko, and R.C. Gupta. 1989. Natural
environment surpasses polluted environment in inducing DNA damage in fish.
Carcinogenesis 10:1337-1339.
Maccubbin, A.E. 1993. DNA adduct analysis in fish: laboratory and field
studies in D.C. Malin and G.K. Ostrander eds., Aquatic Toxicology: Molecular,
Biochemical, and Cellular perspectives, Lewis Pub., Boca Raton.
Malins, D.C., and S.J. Gunselman. Fourier-transform infrared spectroscopy
and gas chromatography-mass spectrometry reveal a remarkable degree of structural
damage in the DNA of wild fish exposed to .HTML chemicals. Proc. Natl. Acad.
Sci. USA. 91:13038-13401.
Malins, D.C., G.K. Ostrander, R. Haimanot and P. Williams. A novel DNA lesion
in neoplastic livers of feral fish: 2,6 -diamino-4-hydroxy-5-formamidopyrimidine.
Carcinogenesis 11:1045-1047.