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GENOTOXICITY, DNA MARKERS, AND TOXICOLOGY

Provided by Isaac Wirgin, New York University, Institute of Environmental Medicine

Summary Papers

Roesijadi G. 1992. Metallothioneins in metal regulation and .HTMLity in aquatic animals. Aquat. Toxicol. 22:81-114.

Stegeman, J.J. and Mark E. Hahn. 1993. Biochemistry and molecular biology of monooxygenases: Current perspectives on forms, functions, and regulation of cytochrome P450 in aquatic species. in D.C. Malins an G.K. Ostrander, eds. Aquatic Toxicology: Molecular, Biochemical, and Cellular Perspectives, Lewis Pub., Boca Raton.

Stegeman, J.J., M. Brouwer, R.T. Di Giulio, L. Forlin, B.A. Fowler, B.M. Sanders, and P.A. Van Veld. 1992. Enzyme and protein synthesis as indicators of contaminant exposure and effect. in R.J. Huggett, R.A. Kimerle, P.M. Mehrle, Jr., and H.L. Bergman, eds. Biomarkers: Biochemical, Physiological, and Histological Markers of Anthropogenic Stress, Lewis Pub, Chelsea, MI.

Van Bendeden, R.J., and G. K. Ostrander. 1993. Expression of oncogenes and tumor supressor genes in teleost fish. in D.C. Malins and G.K. Ostrander, eds. Aquatic Toxicology: Molecular, Biochemical, and Cellular Perspectives, Lewis Pub., Boca Raton.

Recent Papers

Fong, A.T., R.H. Dashwood, R. Cheng, C. Mathews, B. Ford, J.D. Hendricks, and G.S. Bailey. 1993. Carcinogenicity, metabolism and Ki-ras proto-oncogene activation by 7,12-dimethylbenz[a]anthracene in rainbow trout. Carcinogenesis 14:629-635.

Hahn, M.E., A. Poland, E. Glover, and J.J. Stegeman. 1994. Photoaffinity labeling of the AH receptor: phylogenetic survey of diverse vertebrate and invertebrate species. Arch. Biochem. Biophys. 310:218-228.

McMahon, G., L.J. Huber, M.J. Moore, J.J. Stegeman, and G.N. Wogan. 1990 Mutations in c-Ki-ras oncogenes in diseased livers of winter flounder from Boston Harbor. Proc. Natl. Acad. Sci. USA. 87:841-845.

Varanasi, U., W.L. Reichet, and J.E. Stein. 1989. 32P-postlabeling analysis of DNA adducts in liver of wild English sole (Parophrys vetulus) and winter flounder (Pseudopleuronectes americanus). Cancer Res. 49:1171-1177.

Wirgin, I., D.C. Currie, and S.J. Garte. 1989. Activation of the K-ras oncogene n liver tumors of Hudson River tomcod. Carcinogenesis 10:2311-2315.

Wirgin, I.I., C. Grunwald, S. Courtenay G.-L. Kreamer, W.L. Reichert, and J.E. Stein. 1994. A biomarker approach to assessing xenobiotic exposure in Atlantic tomcod from the North American Atlantic coast. Environ. Health Perspect. 102:764-770.

Controversy
What is the role of oxygen radicals in comparison to bulky PAH adducts in the initiation of DNA damage in cancer-prone fish?

Kurelec, B., A. Garg, S. Krca, M. Chacko, and R.C. Gupta. 1989. Natural environment surpasses polluted environment in inducing DNA damage in fish. Carcinogenesis 10:1337-1339.

Maccubbin, A.E. 1993. DNA adduct analysis in fish: laboratory and field studies in D.C. Malin and G.K. Ostrander eds., Aquatic Toxicology: Molecular, Biochemical, and Cellular perspectives, Lewis Pub., Boca Raton.

Malins, D.C., and S.J. Gunselman. Fourier-transform infrared spectroscopy and gas chromatography-mass spectrometry reveal a remarkable degree of structural damage in the DNA of wild fish exposed to .HTML chemicals. Proc. Natl. Acad. Sci. USA. 91:13038-13401.

Malins, D.C., G.K. Ostrander, R. Haimanot and P. Williams. A novel DNA lesion in neoplastic livers of feral fish: 2,6 -diamino-4-hydroxy-5-formamidopyrimidine. Carcinogenesis 11:1045-1047.

 

 

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