Many faculty work on more than one of these topics; we have listed them by their primary focus.

• Cancer Biology
• Cell cycle, DNA replication, recombination and repair
• Development
• Eukaryotic cell biology and cell signaling
• Genomics, computational and structural biology
• Human Genetics and Gene Therapy
• Microbial pathogenesis and gene therapy
• Neurobiology and behavior
• Population genetics and evolution
• Regulation of gene expression
• Plant Biology

Cancer Biology

• Wen-Tien Chen, Professor, Medicine /Neoplastic Diseases (SBU)
  Cancer Invasion and Angiogenesis
• Howard Crawford, Assistant Professor, Pharmacological Sciences (SBU)
  Matrix metalloproteases and pancreatic cancer
• Gregory Hannon, Professor, Cold Spring Harbor Laboratory
  Growth control in mammalian cells; post-transcriptional gene silencing
• Yuri Lazebnik, Professor, Cold Spring Harbor Laboratory
  Cancer; cell fusion; apoptosis
• Christopher S. Lee Professor, Department of Urology, SBU
  Urologic Oncology, Tumor Immunology
• Scott Lowe, Professor, Cold Spring Harbor Laboratory
  Modulation of apoptosis; chemosensitivity; senescence by cancer genes
• Kenneth Marcu, Professor, Biochemistry (SBU)
  Gene function and regulation in innate and adaptive immunity and neoplasia
• Ute Moll, Professor, Pathology (SBU)
  Function and Regulation of the p53 gene family in Normal and Cancer Cells
• Senthil Muthuswamy, Associate Professor, Cold Spring Harbor Laboratory
  Understanding cancer initiation using three-dimensional epithelial structures
• Scott Powers, Associate Professor, Cold Spring Harbor Laboratory
  Genomics; cancer genes; signal transduction; yeast genetics; bioinformatics.
• Linda Van Aelst, Professor, Cold Spring Harbor Laboratory
  Signal transduction; Ras and Rho proteins; tumorigenesis; neuronal development
• Michael Wigler, Professor, Cold Spring Harbor Laboratory
  Genomics; cancer genes; signal transduction; yeast genetics; bioinformatics
• Wei-Xing Zong , Assistant Professor, Department of Molecular Genetics & Microbiology
• Molecular regulation of apoptotic and necrotic cell death.

Cell cycle, DNA replication, recombination, and repair

• Daniel Bogenhagen, Professor, Pharmacology (SBU)
  control of expression of dual-function genes; features of nuclear-mitochondrial interactions
• Bruce Futcher, Associate Professor, Cold Spring Harbor Laboratory
  Cancer, cell cycle, cyclins, microarrays, computational biology, yeast genetics.
• Arthur Grollman, Distinguished Professor and Chairman, Pharmacology (SBU)
  Mechanisms of DNA repair and mutagenesis in mammalian cells
• Nancy Hollingsworth, Associate Professor, Biochemistry and Cell Biology (SBU)
  Meiotic chromosome synapsis, recombination, and segregation in yeast
• Janet Leatherwood, Assistant Professor, Molecular Genetics and Microbiology (SBU)
  Cell cycle control of DNA replication
• Arne Stenlund, Associate Professor, Cold Spring Harbor Laboratory
  DNA replication of bovine papillomavirus
• Bruce Stillman, President, Cold Spring Harbor Laboratory
  DNA replication; chromatin assembly; biochemistry; yeast genetics; cancer; cell cycle

Development

• Michael Frohman, M.D., Ph.D., Professor and MSTP Director, Pharmacology (SBU)
  Regulation of membrane vesicle trafficking and phototransduction by lipid-modifying signaling enzymes
• J. Peter Gergen, Professor, Biochemistry and Cell Biology (SBU) 
  Regulation of gene expression and the genetics of development
• Michael Hadjiargyrou, Associate Professor, Biomedical Engineering (SBU)
  Innovative approaches for engineering new skeletal tissue utilizing knowledge derived from molecular/cellular biology and biomaterials
• Bernadette Holdener, Associate Professor, Biochemistry and Cell Biology (SBU)
  Genetic regulation of mesoderm induction in the mouse
• Alea Mills, Associate Professor, Cold Spring Harbor Laboratory
  Functional genomics; tumorigenesis; development
• Howard Sirotkin, Assistant Professor, Neurobiology and Behavior (SBU)
  Specification and patterning of the neural plate, vertebrate developmental genetics
• Ken-Ichi Takemaru , Assistant Professor, dept. of Pharmacological Sciences (SBU)
  Wnt signalling in development and disease
• Gerald H. Thomsen, Associate Professor, Director, Graduate Program in Genetics, Dept. of Biochemistry and Cell Biology (SBU)
  Inductive signaling and molecular mechanisms of pattern formation in vertebrate and cnidarian embryos.

Eukaryotic cell biology and cell signaling

• Carl Anderson, Senior Geneticist, Brookhaven National Laboratory
  Cell Cycle Control and the Cellular Response to DNA Damage
• Deborah Brown, Professor, Biochemistry and Cell Biology (SBU)
  Structure and function of sphingolipid and cholesterol-rich membrane domains
• Nicholas Carpino Assistant Professor, Molecular Genetics & Microbiology
  Positive and Negative Regulation of T cell Receptor Signaling
• Neta Dean, Associate Professor, Biochemistry and Cell Biology (SBU)
  Regulation of Glycosylation and cell wall biogenesis in yeast
• Dale Deutsch Professor, Department of Biochemistry and Cell Biology, SBU
  Metabolism of the Endocannabinoids, Anandamide and 2-AG
• Berhane Ghebrehiwet Professor, Department of Medicine, SBH
  Study of the function and molecular biology and three-dimensional structure of cell surface receptors or binding proteins specific for human C1q.
• Tatsuya Hirano, Associate Professor, Cold Spring Harbor Laboratory
  Chromosome architecture and dynamics; mitosis; SMC proteins
• James Konopka, Associate Professor, Molecular Genetics and Microbiology (SBU)
  G protein-coupled receptor signal transduction; fungal pathogenesis (Candida albicans).
• William Lennarz, Distinguished Professor and Chairman, Biochemistry and Cell Biology (SBU)
  Biosynthesis and catabolism of glycoproteins; role of cell surface glycoproteins in fertilization and early development
• Craig Malbon, Professor, Pharmacology (SBU)
  Regulation of hormone-sensitive effector systems
• Aaron Neiman, Assistant Professor, Biochemistry and Cell Biology
  Molecular mechanisms that control the formation of spores
• Clinton Rubin, Professor and Chair, Bioengineering (SBU)
  Biophysical stimuli - (i.e., mechanical, electrical, temperature, magnetic, pressure) mediated growth, healing, and homeostasis of bone
• David Spector, Professor, Cold Spring Harbor Laboratory
  Cell biology; gene expression; nuclear structure; microscopy
• William Tansey, Professor, Cold Spring Harbor Laboratory
  Oncogene regulation; transcription; protein destruction
• Thomas White, Associate Professor, Physiology and Biophysics (SBU)
  Gap junction functions defined by genetic diseases and gene knockouts

Genomics, computational and structural biology

• Dax Fu, Assistant Professor, Pharmacology/Brookhaven National Laboratory
  Structures of representative channel and transporter proteins
• Leemor Joshua-Tor, Professor, Cold Spring Harbor Laboratory
  Structural Biology and Molecular Recognition, nucleic acid regulation, RNAi
• Richard McCombie, Professor, Cold Spring Harbor Laboratory
  DNA sequencing; computational molecular biology; human genome project; biotechnology
• Vivek Mittal, Assistant Professor, Cold Spring Harbor Laboratory;
  Tumor angiogenesis; bone marrow stem cells; transcription profiling; RNA interference; mouse models of cancer
• John Reinitz, Professor, Applied Math and Statistics (SBU)
  Computational biology; modeling of gene regulatory networks in Drosophila's segmentation pattern
• Steven O. Smith Professor and Director of Structural Biology,Department of Biochemistry and Cell Biology (SBU)
  Molecular mechanisms of signal transduction by G protein-coupled receptors and receptor tyrosine kinases and the mechanism of selectivity and gating by ion channel proteins.
• Michael Zhang, Professor, Cold Spring Harbor Laboratory
  Mathematical and statistical methods to identify functional elements in eucaryotic genomes, especially the genes and their control and regulatory elements

Human Genetics and Gene Therapy

• Wadie Bahou, Professor, Medicine-Hematology (SBU)
  Vascular biology and thrombosis; molecular genetics
• Craig Cohen, Assistant Professor, Research Director
  Neonatology
• Paul Freimuth, Associate Chairman, Biology Dept., Broohaven National Laboratory
  Structural basis for protein-protein interactions; protein folding behavior and the development of strategies to optimize protein folding efficiency
• Eli Hatchwell, Investigator, ColdSpring Harbor Laboratory
  Sporadic human genetics disease
• Patrick Hearing, Professor, Molecular Genetics and Microbiology (SBU)
  Adenovirus regulation of cellular proliferation and gene expression; adenovirus vectors for human gene therapy
• Nancy Mendell, Professor, Applied Math and Statistics (SBU)
  Biostatistics
• Johnathan Sebat, Assistant Professor, Cold Spring Harbor
  Copy number variation; segmental duplication; genetics; neurogenetics; ROMA; microarray

Microbial pathogenesis and gene therapy

• Jorge Benach, Professor, Molecular Genetics and Microbiology (SBU)
  Pathogenesis of spirochetal infections and their host responses
• James Bliska, Professor, Molecular Genetics and Microbiology (SBU)
  Molecular and cellular basis of bacterial-host cell interactions
• Carol Carter, Professor, Molecular Genetics and Microbiology (SBU)
  Retroviral Viral Assembly and Post-Assembly Events
• Martha Furie, Professor, Pathology (SBU)
  Interactions between bacterial pathogens and host cells of innate immunity
• Erich Mackow, Associate Professor, Medicine (SBU)
  Rotavirus and Hantavirus Pathogenesis; Virus Directed Cell Signaling and Transcriptional Responses; Protein-Membrane Interactions; Viral Attachment and Entry
• Jacek Skowronski, Associate Professor, Cold Spring Harbor Laboratory
  HIV pathogenesis; nef gene; signal transduction; protein sorting; animal models
• David Thanassi, Assistant Professor, Molecular Genetics and Microbiology (SBU)
  Secretion of virulence factors by bacterial pathogens; pilus biogenesis by uropathogenic Escherichia coli.
• Eckard Wimmer, Professor, Molecular Genetics and Microbiology (SBU)
  Molecular biology of poliovirus and hepatitis C virus replication and basis of picornaviral pathogenesis.

Neurobiology and behavior

• Turhan Canli , Graduate Program in Genetics and Department of Psychology
  Genomic imaging of emotion, personality, and individual differences
• Hollis Cline,Professor, Cold Spring Harbor Laboratory
  Molecular control of neuronal plasticity
• Holly Colognato,Assistant Professor, Pharmacology, SBU
  Extracellular matrix in the brain: roles during development and during neurodegeneration
• Joshua Dubnau Assistant Professor, Cold Spring Harbor Laboratory
  Learning, memory & genetics behavior
• Grigori Enikolopov,Associate Professor, Cold Spring Harbor Laboratory
  Stem cells; neurogenesis; development; signal transduction
• Z. Josh Huang, Associate Professor, Cold Spring Harbor Laboratory
  Neuroscience; experience-dependent development of the neocortex; mouse genetics; neurotrophins
• Maurice Kernan, Associate Professor, Neurobiology and Behavior (SBU)
  Molecular basis of mechanical senses
• Roberto Malinow, Professor, Cold Spring Harbor Laboratory
  Neuroscience; synaptic transmission; synaptic plasticity; learning and memory
• Mirjana Maletic-Savatic, Assistant Professor, Department of Neurology
  Mechanisms that lead to the differentiation of neural progenitor cells into neuronal lineages and to identify neural progenitor cell biomarkers that will enable tracing of these cells in vivo
• Styliani-Anna Tsirka, Associate Professor, Pharmacological Sciences
  Tissue Plasminogen Activator in the Mammalian Hippocampus Neuronal-microglial interactions in the physiology and pathology of the central nervous system
• Yi Zhong, Professor, Cold Spring Harbor Laboratory
  Signal transduction, Learning and Memory

Population genetics and evolution

• Michael A. Bell, Professor, Ecology and Evolution (SBU)
  Patterns of morphological variation in time and space in the threespine stickleback fish, Gasterosteus aculeatus
• Geeta Bharathan, Associate Professor, Ecology and Evoultion (SBU)
  Phylogenetic and morphological studies of Dioscorea11, the genus of true yams, comparative analyses of trends in leaf evolution and correlations between genome size and reproductive development in angiosperms
• Walter Eanes, Professor, Ecology and Evolution (SBU)
  Population genetics and molecular evolution of Drosophila as a model system
• John True, Assistant Professor, Ecology and Evolution (SBU)
  Genetic and evolutionary mechanisms underlying phenotypic divergence and speciation using Drosophila species as model organisms

Regulation of gene expression

• Paul Bingham, Associate Professor, Biochemistry and Cell Biology (SBU)
  Genetics of development and regulation of gene expression
• John Dunn, Microbiologist, Brookhaven National Laboratory
  Transcription, processing, and translation of RNA
• Wali Karzai, Associate Professor, Biochemistry and Cell Biology (SBU)
  SmpB SsrA quality control system for protein tagging, directed degradation, and ribosome rescue
• Adrian Krainer, Professor, Cold Spring Harbor Laboratory
  Posttranscriptional control of gene expression; pre-mRNA splicing mechanisms, fidelity and genetic diseases; alternative splicing; RNA-protein interactions; cell-free systems
• Nancy Reich, Professor, Molecular Genetics & Microbiology.)
  Signal Transduction and Activation of Gene Expression by Cytokines & Cellular Defense Responses to Viral Infection
• Rolf Sternglanz, Distinguished Professor, Biochemistry and Cell Biology (SBU)
  Yeast molecular genetics

Plant Biology

• Vitaly Citovsky, Professor, Biochemistry and Cell Biology (SBU)
  Nuclear transport and intercellular communication in plants
• David Jackson, Professor, Cold Spring Harbor Laboratory
  Plant development; genetics; cell-to-cell mRNA and protein trafficking
• Wolfgang Lukowitz, Assistant Professor, Cold Spring Harbor
  Genetics, development, plant biology; macromolecular transport between and within cells during host-pathogen interactions
• Robert Martienssen, Professor, Cold Spring Harbor Laboratory
  Plant genetics; transposons; development; gene regulation; DNA methylation
• Marja Timmermans, Associate Professor, Cold Spring Harbor Laboratory
  Plant development; axis specification; miRNAs; stem cell function

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