An introduction to the rapidly developing field of genomics. Initial lectures provide a foundation in genomic structure across the tree of life (prokaryote and eukaryote). This is followed by examination of specific forces that cause variation in genomic content both within and between species. We then discuss how to sequence, assemble and analyze genomes. Finally we focus on the architecture and evolution of the human genome and compare it to non-human primate and ancient hominin genomes, and examine how the study of non-human primates can aid human health.
Prerequisite: BIO 201, BIO 202
Advisory Prerequisite: BIO 302, BIO 312, and BIO 211
This course provides a computer lab-based introduction to comparative genomics, molecular evolutionary analysis, and next generation sequencing (NGS) data and analysis. Activities will include familiarization with both web-based and command-line tools for analyzing genomic data and summarizing/visualizing results. Lectures and background reading will provide an introduction to basic principles of genomics to inform computer-based hands-on activities. Students will be evaluated based on computer lab assignments, as well as a final group project that applies learned concepts and approaches to a novel research question.
Prerequisite: BIO 302 or EBH 380
An advanced course in human genetics. Topics include genotype/phenotype associations, the genetic architecture of disease/phenotypes, human population genetics, methylation, and ancient DNA. This class is meant to build on major concepts in human genetic research introduced in other courses. The course will emphasize hands-on engagement with genetic data and critical reading of scientific papers. Computer laboratory analysis/assignments will make up a major component of this class. Students will be evaluated based on computer assignments and a final group research project. EBH majors will have priority to register.
Prerequisite: BIO 302, BIO 320 or EBH 380
Hands-on experience with laboratory methods to detect and analyze molecular (DNA) variation in Drosophila, bacteria, and humans as well as an introduction to examining human genetic diversity using public resources. This course has an associated fee. Please see www.stonybrook.edu/coursefees for more information.
Prerequisite: C or higher in BIO 201; C or higher in BIO 202; BIO 205 or BIO 207
Advisory Pre- or Corequisite: One of the following: BIO 320, BIO 321, BIO 351, or BIO 354