Paul M. Bingham
Ph.D., Harvard University, 1979
Associate Professor, Department of Biochemistry and Cell Biology
Research Interests: Genetics of development and regulation of gene expression
Our interest is in the intimately interconnected problems of the genetic
control of development and the developmental control of gene expression.
Most of our work makes use of the powerful genetic system offered by Drosophila.
Exploiting this system has led us to analysis of a number of different problems.
A recent example is the developmental control of nuclear pre-mRNA processing
(see references below). Control of gene expression at the level of splicing
is a central, widely occurring phenomenon in animals; however, its molecular
basis is very poorly understood. We have identified and cloned one of the
few splicing regulators currently known (reviewed in Bingham et al., 1988)
and have exploited this unique opportunity to investigate metazoan splicing
regulation. Among other things these studies have led us to remarkable new
insights into the organization of eukaryotic nuclei (Li and
Bingham, 1991).
Chou, T.-B., Mims, I., Zachar, Z. and Bingham, P.M. (1988). On/off regulation
of gene expression at the level of splicing. Trends Genet. 4: 134-138.
Li, H. and Bingham, P.M. (1991). Arginine/Serine rich domains of the su(wa)
and tra RNA processing regulators
target proteins to a subnuclear compartment implicated in splicing. Cell
67: 335-342.
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